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On 30 October 2025, the EACR hosted a webinar in collaboration with Bio-Rad, one of our valued EACR Industry Partners. In this webinar, Leisa Jackson, lead R&D scientist at Biodesix, discussed her recent development work with two new assay formats that provide coverage of 11 variants commonly found in endocrine therapy-resistant HR+, HER2- metastatic breast cancer patients.
Thanks to Leisa and Bio-Rad, we are able to provide free on-demand access to the webinar recording, which can be found above.
Talk abstract
The Bio-Rad QX600 System is a next-generation droplet digital PCR platform designed for advanced target multiplexing. In this webinar, we report on our early access evaluation of the ddPLEX EGFR, KRAS, BRAF Multiplex Assay, which can simultaneously detect up to 37 key NSCLC variants in a single well using the QX600 System. We assessed assay performance in our CAP/CLIA accredited, ISO certified, and NYS CLEP approved clinical laboratory using remnant, de-identified cfDNA specimens from NSCLC donors.
This presentation also showcased Biodesix’s development work with the recently available ddPLEX ESR1 Mutation Detection Kit and ESR1 extended variant (EXV) Screening Assay. Together, the two assay formats provide coverage of 11 variants commonly found in endocrine therapy-resistant HR+, HER2- metastatic breast cancer patients. We observed detection at as low as 0.025% variant allele frequency in a plasma background. This level of sensitivity will be required for the early detection of acquired resistance to aromatase inhibitors in cell-free DNA.
Speaker
Leisa Jackson, Lead R&D scientist, Biodesix, Inc.
Leisa Jackson is a lead R&D scientist at Biodesix, Inc., in Louisville, Colorado. She has over 20 years of experience in molecular biology research, with a focus on translational science applications, including 10 years developing ddPCR and NGS assays for oncology diagnostic tests for both RUO and IVD applications. She earned her Bachelor of Science degree in Biological Science from Florida State University and has contributed to research in academic (FSU, Duke University, CU Boulder), clinical (National Jewish Health), and industry (Biodesix, Inc. and Invitae Corp.) settings.
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