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The EACR’s Top 10 Cancer Research Publications: April 2019

October 17, 2025
EACR top 10 cancer research publications

The EACR’s Top 10 Cancer Research Publications is a regular summary of the most interesting and impactful recent papers in cancer research. It is curated by the Board of the European Association for Cancer Research (EACR).

The list below appears in no particular order, and the summary information has been provided to us by the authors.

Use the dropdown menu or ‘Previous’ and ‘Next’ buttons to navigate the list.

12. Liked the list? Did you find it interesting?

  • 1. Somatic mutant clones colonize the human esophagus with age
  • 2. Age-related remodelling of oesophageal epithelia by mutated cancer drivers
  • 3. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
  • 4. A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
  • 5. Organoid Modeling of the Tumor Immune Microenvironment
  • 6. Sensitive tumour detection and classification using plasma cell-free DNA methylomes
  • 7. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
  • 8. WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
  • 9. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
  • 10. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
  • 11. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
  • 12. Liked the list? Did you find it interesting?
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Observant readers may notice that our ‘Top 10’ list has 11 entries. We shortlisted so many great papers over the last months that we couldn’t limit ourselves to 10!

12. Liked the list? Did you find it interesting?

  • 1. Somatic mutant clones colonize the human esophagus with age
  • 2. Age-related remodelling of oesophageal epithelia by mutated cancer drivers
  • 3. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
  • 4. A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
  • 5. Organoid Modeling of the Tumor Immune Microenvironment
  • 6. Sensitive tumour detection and classification using plasma cell-free DNA methylomes
  • 7. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
  • 8. WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers
  • 9. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
  • 10. A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
  • 11. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
  • 12. Liked the list? Did you find it interesting?
Previous
Next
Tags: EACR BoardEACR Top Ten Cancer Research Publicationspublication

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    • The EACR’s Top 10 Cancer Research Publications is a regular summary of the most interesting and impactful recent papers in cancer research. It is curated by the Board of the European Association for Cancer Research (EACR).
  • 12. Liked the list? Did you find it interesting?
  • 12. Liked the list? Did you find it interesting?
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